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KMID : 1200020170410040251
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Diabetes & Metabolism Journal
2017 Volume.41 No. 4 p.251 ~ p.262
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The Effectiveness of Green Tea or Green Tea Extract on Insulin Resistance and Glycemic Control in Type 2 Diabetes Mellitus: A Meta-Analysis
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Yu Jinyue
Song Peige
Perry Rachel
Penfold Chris
Cooper Ashley R.
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Abstract
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Green tea or green tea extract (GT/GTE) has been demonstrated to reduce insulin resistance and improve glycemic control. However, evidence for this health beneficial effect is inconsistent. This systematic review evaluated the effect of GT/GTE on insulin resistance and glycemic control in people with pre-diabetes/type 2 diabetes mellitus (T2DM). Ovid MEDLINE, Embase, AMED, Web of Science, and the Cochrane Library were searched up to April 2017 for randomised controlled trials of participants with pre-diabetes or T2DM, where the intervention was GT/GTE. Meta-analysis was performed to assess the standardised mean difference (SMD) in biomarkers of insulin resistance and glycemic control between GT/GTE and placebo groups. Six studies (n=382) were pooled into random-effects meta-analysis. Overall, no differences were found between GT/GTE and the placebo for glycosylated hemoglobin (HbA1c: SMD, ?0.32; 95% confidence interval [CI], ?0.86 to 0.23), homeostatic model assessment for insulin resistance (HOMA-IR: SMD, 0.10; 95% CI, ?0.17 to 0.38), fasting insulin (SMD, ?0.25; 95% CI, ?0.64 to 0.15), and fasting glucose (SMD, ?0.10; 95% CI, ?0.50 to 0.30). No evidence support the consumption of GT/GTE could reduce the levels of HbA1c, HOMA-IR, fasting insulin, or fasting glucose in people with pre-diabetes/T2DM. However, the studies included were small and of varying quality.
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KEYWORD
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Diabetes mellitus, type 2, Glycemic control, Green tea, Insulin resistance, Meta-analysis
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